Running head: Roles of mPGES-1 in angiogenesis and ulcer healing
نویسندگان
چکیده
Role of microsomal prostaglandin E synthase-1 in the facilitation of 1 angiogenesis and the healing of gastric ulcers 2 3 Takako Ae 2, , Takashi Ohno , Youichiro Hattori , Tatsunori Suzuki , 4 Kanako Hosono , Tsutomu Minamino 2, ,Takehito Sato 2, ,Satoshi Uematsu, 5 Shizuo Akira, Wasaburo Koizumi, and Masataka Majima 2 6 7 Department of Pharmacology, Kitasato University School of Medicine 8 Department of Molecular Pharmacology, Graduate School of Medicine 9 Department of Gastroenterology, Kitasato University School of Medicine 10 Department of Host Defense, Research Institute for Microbial Diseases, Osaka 11 University, Osaka 565-0871, Japan 12 Running title: mPGES-1 and gastric ulcers 13 14 Running head: Roles of mPGES-1 in angiogenesis and ulcer healing 15 16 There is no conflict of interest to disclose. 17 *Correspondence to: 18 Masataka Majima, MD & PhD 19 Department of Pharmacology, Kitasato University School of Medicine, 20 Kanagawa, 228-8555, Japan 21 Phone: +81-42-778-8822 22 Fax: +81-42-778-7604 23 E-mail:[email protected] 24 25 26 Articles in PresS. Am J Physiol Gastrointest Liver Physiol (September 2, 2010). doi:10.1152/ajpgi.00013.2010
منابع مشابه
Role of microsomal prostaglandin E synthase-1 in the facilitation of angiogenesis and the healing of gastric ulcers.
The importance of prostaglandin E(2) in various pathophysiological events emphasizes the necessity of understanding the role of PGE synthases (PGESs) in vivo. However, there has been no report on the functional relevance of microsomal PGES-1 (mPGES-1) to the physiological healing processes of gastric ulcers, or to angiogenesis, which is indispensable to the healing processes. In this report, we...
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